ピリドキサール誘導体の合成ならびにその生化学的研究

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概要

• 論文の詳細を見る

• In order to examine the relation between the antitubercular activity and vitamin B_6 activity, several kinds of mercaptal and isoquinoline derivatives of pyridoxal or pyridoxal-phosphate were synthesized, and biochemical tests were performed on these compounds. Mercaptals were prepared by the reaction of ethylmercaptan with pyridoxal or pyridoxal-phosphate, and these compounds had on antitubercular activity for Mycobacterium tuberculosum avium or human-type tubercle bacilli, H_<37>Rv strain. Vitamin B_6 activity was confirmed on pyridoxal-diethylmercaptal, pyridoxal-6,8-thioctic acid mercaptal and the compounds prepared by the reaction of Dopa with pyridoxal or pyridoxal-phosrphate. Supposing that the inhibition of vitamin B_6-enzyme by Dopa was due to the combination of pyridoxal phosphate and Dopa, tetrahydroisoquinoline carbonate was synthesized. Pyridoxal-or pyridoxal-phosphate-6,8-thioctic acid mercaptals showed only weeker action than pyridoxal-phosphate for tryptophanase of the Escherichia coli communior.

• 日本ビタミン学会の論文

著者

• 立松 晃

  名古屋大学医学部山田内科教室

関連論文

• 18.ビタミンB_6の硫酸エステルにかんする研究(II) : ピリドキサールモノエチルアセタール-3-硫酸について(第13回大会研究発表要旨)
• Pyridoxal-DL-dihydro-α-lipoic acid mercaptalおよびPyridoxalphosphate-DL-dihydro-α-lipoic acid mercaptalの研究
• 3.Pyridoxal-DL-dihydro-α-lipoic acid mercaptal hydrochloride, Pyridoxalphosphate-DL-dihydro-α-lipoic acid mercaptalに関する研究(I)(第12回大会研究発表要旨)
• ピリドキサール誘導体の合成ならびにその生化学的研究

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