TOXOPYRIMIDINE群物質の研究 : (XII)疾走痙攣時および予防時のGLUTAMIC-DECABOXYLASE, γ-AMINOBUTYLIC-α-KETOGLUTARIC-TRANSAMINASE活性の変動について

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概要

• 論文の詳細を見る

• In an attempt to clarify the running fit from the standpoint of brain metabolism, the enzyme system involved in the metabolic pathway from glutamic acid to γ-aminobutyric acid and then to succinic semialdehyde in the brain was studied. For inducing the running fit, 2-methyl-4-amino-5-hydroxymethylpyrimidine and thiosemicarbazide were used and pyridoxine and 2-methyl-4-amino-5-aminomethylpyrimidine were used for the suppression. It was found that at the time of the running fit, glutamic-decarboxylase was inhibited whereas when the seizure was suppressed, there is no inhibition. There was no inhibition of the γ-aminobutyric-α-ketoglutaric-transaminase. The findings suggest that γ-aminobutyric acid is decreased during the running fit.

• 日本ビタミン学会の論文

著者

• 小林 繁郎

  大阪大学医学部小児科学教室

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• TOXOPYRIMIDINE群物質の研究 : (XII)疾走痙攣時および予防時のGLUTAMIC-DECABOXYLASE, γ-AMINOBUTYLIC-α-KETOGLUTARIC-TRANSAMINASE活性の変動について

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