肝障害時におけるパントテン酸代謝 : (III)実験的肝障害ウサギのパントテン酸代謝

概要

論文の詳細を見る
In acute experimental CCl_4 poisoning of rabbits the urinary excretion of pantothenic acid decreased. It reached the lowest level on the 4th day and returned to normal by the 7th day. In chronic liver damage, the urinary pantothenic acid decreased gradually until the end of the experiment (3 monthes later). The increase of urinary pantothenic acid following the intramuscular administration of calcium pantothenate was also depressed in both groups of animals. In acute histologically severe cases, the increase was found to be greater than that of the control animals. The pantothenic acid content of liver, especially the bound form, was less than normal in both groups. These results led to the conclusion that abnormal metabolism of pantothenic acid may exist in these animals.
日本ビタミン学会の論文