トリコマイシンの生産に関する研究 (第2報) : 培養条件の検討

概要

論文の詳細を見る
Employing strains of high productivity, influence of several culture conditions on the production of trichomycin were investigated by means of shake-flask and tank culture.Corn meal was the most favorable nutrient source which supported maximum growth and high productivity throughout the culture period. Dried yeast, added to the corn medium greatly enhanced the mycelial growth.Supplement of corn-steep liquor caused an increase in the intracellular quantity of the antibiotic without appreciable stimulation of growth. The effectiveness of corn-steep liquor supplied was not revealed in the presence of high concentration of phosphate, iron or dried yeast in the medium.The effect of agitation speed, within the range of our experiments, upon trichomycin yield seemed to be insignificant in practical submerged fermentation, although it was perceived in shaken cultures.
公益社団法人日本生物工学会の論文
1962-06-15