トリコマイシンの生産に関する研究 : (第3報) 培養経過とトリコマイシンの消長

概要

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The development of the trichomycin-producing organism in corn meal medium appeared to take place in two consecutive growth phases. Primary growth was observed within 50 hrs, with and exponential increase in oxygen-uptake and formation of NH_3.Growth occurred again over a cultivation period between 80 and 90 hrs. Oxygen uptake rose again and NH_3 was used up in this stage. All the metabolic activities were diminished in the subsequent stage of autolysis.Broth potency increased linearly with the development of mycelia and reached a maximum value at 90 hrs. Antibiotic activity of the powdery preparation of trichomycin obtained from mycelia exhibited also the highest value at 90 hrs. Trichomycin yield increased until the end of the cultivation period (140 hrs).Methods of seeding and medium components affected the antibiotic yield, but little change was observed in the time-course of activities of trichomycin preparations obtained therefrom.These results indicate that the formation of trichomycin is not strictly of the growth-associated type.
公益社団法人日本生物工学会の論文
1962-07-15