甲状腺機能異常状態におけるビタミンB_1代謝にかんする研究 : (III)ウサギのビタミンB_1-^<35>S代謝におよぼす甲状腺ホルモンの影響

概要

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Thiamine-^<35>S was injected intravenously with rabbit of hypermetabolism caused by continuous administration of triiodothyronine or with hypometabolism by thyroidectomy. In hypermetabolic animals, ^<35>S contents of liver, blood, kidney and testes increased although urinary ^<35>S excretion decreased as compared with controls. Urinary excretion of ^<35>S in thiamine metabolites increased more during 5 hrs. following injection than thiamine-^<35>S, indicating that the degradation of thiamine occured a little more progressively than that of controls. These results suggest that hypermetabolic animal was in a state of thiamine deficiency. In hypometabolic animals, ^<35>S content of blood, kidney and lung increased and ^<35>S excreted in urine increased as compaired with controls. Urinary ^<35>S in thiamine metabolite decreased during 5 hrs. after injection, while ^<35>S in thiamine increased than the controls. The results showed that in hypometabolic animal, thiamine deficiency is not seen, and that thiamine simply passes through the animal.
日本ビタミン学会の論文
1966-03-25