甲状腺機能異常状態におけるビタミンB_1代謝にかんする研究 : (I)臨床的研究

概要

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A thiamine loading test (subcutaneous injection of 10mg) was performed on 21 patients with hyperthyroidism, 6 patients with hypothyroidism, 8 patients with simple goitre and 10 healthy subjects, as control. Phosphorylated and free thiamines were determined in blood after 30 and 60 min. of injection and also in 3 hrs. urine. In healthy subjects, total thiamine level in fasting blood was 5.1±1.25μg/dl and it increased to 8.3±1.79 μg/dl at one hr. after loading. Ester ratio in blood at that time was 29.5±10.39%. Urinary excretion of thiamine was 40.3±7.59% of administered amount during 3hrs. after injection. In hyperthyroidism, a remarkable increase of esterified thiamine and of ester ratio in blood and a decrease of urinary thiamine after loading as compared with those of controls were observed. On the other hand, in hypothyroidism, a remarkable increases of total blood thiamine and increase of urinary thiamine was found but ester ratio showed only a slight elevation. In all patients, examined, there was inverse correlations between ester ratio and urinary thiamine, total blood thiamine and serum protein-bound iodine, total blood thiamine and basal metabolic rate, respectively. In addition, there was direct correlation between ester ratio and serum protein-bound iodine.
日本ビタミン学会の論文
1966-03-25