ビタミンB_1大量投与にかんする臨床的ならびに実験的研究 : (IV)ビタミンB_1大量投与時の吸収, 排泄と体内貯留

概要

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Studies were made on the distribution of thiamine in body of rat, its excretion in urine and faeces, and the amount of thiamine decomposed in the body after an excessive administration of thiamine. When 500μg of thiamine hydrochloride per 100g body weight was given subcutaneously for 20 days to young rat, total excreted thiamine was 60% of given dose and the amount decomposed in the body was calculated as 36%. In 24 hours experiment, the elimination and destruction rates were 48.5 and 25.8%, respectively. In the case of 500μg per 100g of thiamine propyldisulfide administration their values were 35 and 25%. It was recognized that the retention of thiamine was lowered by the carbon tetrachloride hepatic injury.
日本ビタミン学会の論文
1966-02-25