市販抗生物質の耐性ブドウ球菌に有効なる抗生物質の研究 : (第3報)35NT号菌の生産する新抗生物質の生物学的性質について

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In this paper, the biological properties of 35NT substance in vitro and in vivo are described.35NT substance is active against Gram-positive bacteria, and inhibits growth of resistant Staphylococcus aureus at a concentration of 0.25-0.5 μg/ml in vitro. (Table 1)The antimicrobial activity of 35 NT substance was not influenced by the addition of human serum to sample solution tested in vitro. (Table 2)Acute toxicity of 35 NT substance was determined by intraperitoneal injection in mice, and the intraperitoneal LD_<50> was 540 mg/kg. (Table 3)The biological properties in vivo were examined by experimental infections of mice with Staphylococcus aureus A-1 strain. A comparision of activities of 35 NT substance and Erythromycin is shown in Table 4. 35 NT substance was effective against Staphylococcus infections in mice at a dosage of 10mg/kg administered intraperitoneally, but no effect was noted when it was given by oral route.
社団法人日本生物工学会の論文
1966-10-25