ビタミンEの化学構造と生理活性 : (II)トコフェロールエステルの活性

概要

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The biological activities of nine kinds of tocopheryl esters were studied by the hemolysis test using dialuric acid. By the test of oral administration, the activities of dl-α-tocopheryl acetate, d1-α-tocopheryl nicotinate, d1-α-tocopheryl glycolate, d1-α-tocopheryl linoleate, d1-α-tocopheryl dihydroxyacetate and d1-α-tocopheryl acid succinate were found to be between 85% and 100% of that of d1-α-tocopherol while the activities of dl-α-tocopheryl phosphoacetate and d-γ-tocopheryl acetate were 25% and 15% of that of d1-α-tocopherol. By the test of intraperitoneal administration, d1-α-tocopheryl glycolate, d1-α-tocopheryl phosphoacetate and d1-α-tocopheryl dihydroxyacetate were found to be as active as d1-α-tocopherol, while the activities of d1-α-tocopheryl acetate, d1-α-tocopheryl nicotinate, d1-α-tocopheryl linoleate and d1-α-tocopheryl acid succinate were corresponding to a half of that of d1-α-tocopherol. The activities of d-α-tocopheryl acid succinate and d-γ-tocopheryl acetate were 70% and 10% of that of d1-α-tocopherol respectively. It was assumed that these differences in the activities of tocopheryl esters might be related to differences in hydrolysis in tissues as well as speed of absorption from the gut.
日本ビタミン学会の論文
1972-05-25