ビタミンEの化学構造と生理活性 : (III)側鎖構造の異なるdl-α-トコフェロール類縁化合物の活性

概要

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The biological activities of tocopherol related compounds which have different isoprene chain ; dl-α-tocopherol (1), 2,5,7,8-tetramethyl-2-(4', 8'-dimethylnonyl)-6-hydroxychroman (2), 2,5,7,8-tetramethyl-2-(4'-methylpenthyl)-6-hydroxychroman (3) and 2,2,5,7,8-pentamethyl-6-hydroxychroman (4), were studied by the hemolysis test using dialuric acid. In vivo test, the activity of (2) was found to be 3〜5% of (1), while (3) and (4) had no activities in 20 mg doses. On the other hands, the activities of (2), (3) and (4) were much higher than that of (1) in vitro test; those were 850,660 and 400% of that of (1) respectively. When the red blood cells treated with these compounds were washed, however, the activities of these compounds except (1) reduced less than half of that before wash. The decreasing ratio of activities of (1), (2), (3) and (4) by washing were 0,50,60 and 90%, respectively.
日本ビタミン学会の論文
1974-02-25