ビタミンB_6の腹水腫瘍細胞へのとりこみ : (II)ピリドキサルおよびピリドキサルりん酸のとりこみ

概要

論文の詳細を見る
Uptake of pyridoxal and pyridoxal phosphate by ascites-sarcoma cells in vitro, has been investigated. Pyridoxal was quickly uptaken against concentration gradient and accumulated in the cells as pyridoxal phosphate. The uptake of pyridoxal was markedly diminished either in the absence of glucose or by decrease of the temperature. Pyridoxal uptake was also diminished in the presence of 2,4-dinitrophenol and sodium fluoride. In contrast, the uptaken amount of pyridoxal phosphate in the cells was smaller than that of pyridoxal, but increased proportionately with the external pyridoxal phosphate concentration. The uptake of pyridoxal phosphate was also influenced with the addition of glucose and metabolic inhibitors and temperature of incubation. Vitamin B_6 analogues, especially 4-deoxypyridoxine inhibited the uptake of pyridoxal and its phosphate by the cells.
日本ビタミン学会の論文
1970-10-25