神経機能回復に対するビタミンB群の作用

概要

論文の詳細を見る
The effect of daily administration of the vitamin B mixture on the functional recovery from the neuropathy induced by the chronic administration of acrylamide and on the regeneration of crushed sciatic nerve in the rat were investisated. The abnormal motor functions were observed by the administration of acrylamide and the vitamin B complex suppressed the lethality and restored the abnormal functions. The mixture of thiamine disulfide (TDS), PIN and aquocobalamin (OH-B_<12>)[3B]was more effective than each component. The further investigation of 3B was carried out. The decrease in the conduction velocity of the nerve resulting from the neuropathy induced by acrylamide was observed, but no decrease was shown in the rat received with 3B and the decreased velocity after the withdrawal of acrylamide was recovered by 3B. The effect of 3B on the electromyogram patterns of the crushed sciatic nerve in the rat was also investigated. 3B prompted the reinnervation of the crushed peripheral nerves. These results suggest that 3B has some favourable functions on the neural regeneration and the functional restoration from the neuropathy.
日本ビタミン学会の論文
1974-08-25