Photodynamic Diagnosis and Therapy as Alternative to the Management of Early Stage Lung Cancer(Interventional Bronchology)

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概要

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• There has been a dramatic expansion in the role of the bronchoscope as a therapeutic instrument, "Interventional Bronchology", not only for advance bronchogenic carcinoma but also for early cancer. There is now considerable interest in the potential of PDT for treating early bronchial carcinoma. Similarly laser light can be used to detect tumors by fluorescence at an early, and therefore more treatable stage, when they may elude routine bronchoscopy. The total number of early stage lung cancer cases was 107 consisting of 126 lesions, and complete remission was obtained in 85 cases (107 lesions) out of 103 cases (126 lesions, 84.9%) and partial remission in 19 lesions. Eighty patients (98 lesions) were disease free from 2 to 200 months, however, 5 patients died with lung cancer. The survival curve was calculated by the Kaplan and Meier method. The overall survival rate is 68.3%. PDD is another aspect of photodynamic reaction. The effectiveness of a new excimer laser endoscopic imaging fluorescence analyzer system using the photosensitizer for the detection of tumors was evaluated. Autofluorescence (550±10nm, green fluorescence) from normal sites, red fluorescence (670 nm) of chlorine e6 in areas of cancer and the red fluorescence/green fluorescence ratio (R/G ratio) as the color image can be detected respectively. The greatest chlorine e6 fluorescence from the lesion was obtained at 3 hour after injection and the fluorescence disappeared at 24 hours. The greatest difference in the fluorescence of chlorine e6 and the R/G ratio in areas of tumor and in normal areas were observed at 5 hours after administration. At this period, chlorine e6 fluorescence from normal sites was negligible. These data suggest that fluorescence photodiagnosis may effective in the detection of cancers.

• 1998-12-25

著者

• KATO Harubumi

  Department of Surgery I, Tokyo Medical College

• Kato Harubumi

  Department Of Gynecology National Hospital Organization Hokkaido Cancer Center

• Ohira T

  Department Of Thoracic Surgery Tokyo Medical University

• FURUKAWA Kinya

  Department of Chest Surgery, Tokyo Medical University

• Furukawa Kinya

  Department Of Surgery Tokyo Medical University

• Furukawa Kinya

  Department Of Chest Surgery Tokyo Medical University

• Furukawa Kinya

  Department Of Chest Surgery Tokyo Medical University Kasumigaura Hospital

• OKUNAKA Tetsuya

  Department of Surgery, Tokyo Medical University

• USUDA Jitsuo

  Department of Thoracic Surgery, Tokyo Medical University

• Usuda Jitsuo

  Department Of Thoracic Surgery Tokyo Medical University

• Okunaka Tetsuya

  Department Of Thoracic Surgery Tokyo Medical University

• Ohira Tatsuo

  東京医科大学 胸部外科

• KUMASAKA Hideo

  First Department of Surgery and Department of Physiology,TOKYO MEDICAL University

• Hiyoshi Toshimitsu

  Department of Surgery, Tokyo Medical University

• Kumasaka Hideo

  Department of Surgery, Tokyo Medical University

• Sakaniwa Nobuyuki

  Department of Surgery, Tokyo Medical University

• Kumasaka Hideo

  First Department Of Surgery And Department Of Physiology Tokyo Medical University

• Kato Harubumi

  Department Of Thoracic Surgery Tokyo Medical University

• Kato Harubumi

  First Department Of Internal Medicine Tokyo Medical University

• Hiyoshi Toshimitsu

  Department Of Surgery Tokyo Medical University

• Usuda Jitsuo

  Department Of Gastroenterology And Hepatology Tokyo Medical University

• Sakaniwa Nobuyuki

  Department Of Surgery Tokyo Medical University

• Okunaka Tetsuya

  Department Of Surgery Tokyo Medical College

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