妊婦における腎糸球體濾過値測定法の吟味

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概要

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• Renal clearance tests have been studied till now by using as indicators some substance (such as urea) that exists physiologically in the body, but it has become possible these days to determine various renal function factors like renal blood flow, glomerular filtration rate, etc. separately by loading various substances as indicators and utilizing the peculiar characteristics of the glomeruli.Although such substances as Inulin, Mannitol and Sodium thiosulfate are being used as indicators in determining the glomerular filtration rates, the two last agents are used more widely in our country because Inulin is rather hard to obtain nowadays.But these two substances are easily reabsorbed while passing through the tubules and the existence of their secretion has also been pointed out. As a matter of fact, this tendency is especially strong with pregnant women and it is said that errors occur frequently especially with Thiosulfate.Although we have solely been using Sodium thiosulfate for the determination of glomerular filtration rates in testing renal functions these past few years, we have this time conducted both Thiosulfate GFR and Mannitol GFR tests simultaneously or in close succession on the same pregnant women to determine if there exist significant errors among individual tests of each group and also studied whether or not there exists a significant difference between the two groups by performing the X^2 test on each group.For the experiment, we used 14 pregnant women between five and ten months pregnant and administered the indicators with intravenous instillation. The result wat that Thiosulfate GFR showed higher values with ten cases, while Man-nitol GFR, with four cases.As df=1,X^2_0=0.5989 and 0.5<p<0.3 (Yates correction), the reliability was 95% and no significant difference could be noted. The same could be said about between the two groups.As the number of cases is small, nothing definite can be said yet but we are of the opinion that both Thiosulfate and Mannitol can be used without any large errors for determining glomerular filtration rates of pregnant women. It is needless to say, however, that the same indicators have to be used as the loading substance, if the tests are to be repeated continuously on the same subjects.

• 社団法人日本循環器学会の論文
• 1958-04-20

著者

• 秋山 敞

  横浜市立大学医学部産婦人科学教室

• 岩橋 五郎

  横浜市立大学医学部産婦人科学教室

• 岩本 直

  機濱市立大學醫學部産婦人科學教室

• 秋山 敞

  機濱市立大學醫學部産婦人科學教室

• 岩橋 五郎

  機濱市立大學醫學部産婦人科學教室

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