高血壓症と副腎皮質機能 (第1報) : 緒論並びに副腎皮質機能測定法及び臨床高血壓症に於ける副腎皮質機能の研究

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概要

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• There are three types of experimental hypertension : pressoreceptor denerved hypertension (Hering, 1927), renal hypertension (Goldblatt, 1934; Page, 1939), and DCA hypertension (Selye, 1943). In these hypertensions, much has been done for the research of cause of hypertension, but each of them can not explain the whole phenomenons of hypertension. Therefore, it is necessary to see the correlation to each other. Selye produced malignant hypertension as well as nephrosclerosis, acute nephritis, and albuminuria in animals by means of long-term administration of DCA. He attributed them to be due to an excess response of pituitary-adrenal system, which was called general adaptation syndrome. However, the relationship between hypertension and pituitary-adrenal system is not so clear that the influence of adrenal cortex on hypertension seemes to be questionable. The auther investigated the function of adrenal cortex by measuring 17-KS excretion in urine in hypertensive patients of various types, Goldblatt's and Page's renal hypertensive dogs, DCA-hypertensive rats, salt hypertensive rats, and also pressoreceptor denerved hypertensive dogs.Method of measurement of urinary 17-KS excretion The auther adopted Miyake's method where Drekter's extraction, Pearson's color reaction and Fraser's equation were applied on the basis of Zimmermann's color reaction.The 1st Experiment : The adrenocortical function in hypertensive patient.The auther performed measurement of 17-KS excretion in urine, of circulating eosinophils count, and 4-hour epinephrine test in hypertensive patients of various types, (one Cushing's syndrome, one acromegaly, 26 essential hypertension, 18 renal hypertension, and one pheochromocytoma) to see adrenocortical function.Results 1) 17-KS excretion in urine Essential hypertension : In 7 of 16 males it showed low values and in 9 normal values. In 6 of 10 females low values and in 4 normal.Renal hypertension : In 9 of 10 males it revealed low values and one normal value.Acromegaly : One male, normal value.Pheochromocytoma : One male, normal value.Cushing's syndrome : One female, high value. This was just one case which showed a high level of urinary 17-KS excretion.2) Circulating eosinophils count Essential hypertension : In 9 of 26 patients, it showed insufficiency.Renal hypertension : In 5 of 12 patients, it showed insufficiency.3) 4-hour epinephrine test Essential hypertension : In 11 of 14 patients, it showed insufficiency.Renal hypertension : In 5 of 6 patients, it showed insufficiency.Acromegaly : In one patient, it showed insufficiency.

• 社団法人日本循環器学会の論文
• 1958-09-20

著者

• 金高 洋一

  京都大學醫學部内科學第三講座

関連論文

• 46) 所謂"Salt-losing Nephritis"の一例(第4回日本循環器學會近畿地方學會總會)
• 高血壓症と副腎皮質機能(第3報) : 第五篇 實驗的食鹽高血壓白鼠に於ける副腎皮質機能 : 第六篇 實驗的失調性高血壓犬に於ける副腎皮質機能 : 第七篇 總括並びに結論
• 高血壓症と副腎皮質機能(第2報) : 第3篇 實驗的腎性高血壓犬に於ける副腎皮質機能 第4篇 實驗的DCA高血壓白鼠に於ける副腎皮質機能
• 高血壓症と副腎皮質機能 (第1報) : 緒論並びに副腎皮質機能測定法及び臨床高血壓症に於ける副腎皮質機能の研究

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