神經循環疲勞症(Neurocirculatory Asthenia)及び類似疾患に對する實驗的研究 (第1報) : 「アルミナ・クリーム」の脊髓蜘網膜下腔注入による家兎の心機能及び情緒反應の變化について
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Neurocircutatory asthenia (Oppenheimer) is thought to be functional circulatory or nervous disorder and anxiety neurosis, but its cause is still unknown. Prof. M. Maekawa concluded that almost of these neuroses may be conditioned somatically by subclinical arachnoiditis adhesiva cerebrospinalis.In this study, I observed the somatic responses and emotional behavior in rabbits, to which almina-cream were injected or vinyl tube filling up with almina-cream were inserted in spinal subarachnoid space. Results are as follows.1. Of 7 cases to which alumina-cream were applicated at the upper thoracic level (D. 1-5), there were sinus tachycardia in 6 cases, and the inverted T wave electrocardiographically in one case. In all 3 cases into which subarachnoid space the vinyl tube filling up with alumina-cream were inserted at the upper thoracic level (D. 2-7), there were, as electrocardiographic changes, the inverted T wave, the depressed ST segment and/or the supraventricular paroxysmal tachycaedia observed.2. Of 5 cases to which alumina-cream were applicated at the cervical level (C. 3-5), there were observed tachypnea in 3 cases and labored respiration in 2 cases.3. The histopathological findings of the hearts of 4 cases accompanied by the electrocardiographic changes showed thickening of the small or middle arteries, especially subendocardial, and accordingly degeneration or necrosis of the myocardial fibers, cell infiltration and proliferation of fibrous tissue around these arteries.4. The histopathological findings of the kidney of the thoracic group were degeneration of tubli and glomeruli, and interstitial cell infiltration.5. "Sham rage" (Bard) were observed in 4 cases of thoracic group and one case of cervical group.6. Alumina-cream were found histochemically in dorsal and central areas of spinal cord.
- 社団法人日本循環器学会の論文
- 1958-09-20
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