Alveolar Ventilation and Dead-space Ventilation During Exercise in Patients with Previous Myocardial Infarction
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AJISAKA, R., WATANABE, S., TOYAMA, M. and YAMAGUCHI, I., Alveolar Ventilation and Dead-space Ventilation During Exercise in Patients with Previous Myocardial Infarction. Adv. Exerc. Sports Physiol., Vol.6, No.1 pp17-23, 2000. We evaluated changes in alveolar ventilation (VA) and dead-space ventilation (VD) in 11 patients with myocardial infarction (MI) and 6 control subjects during an ergometer exercise test. We also investigated the relations between these parameters and the lactate and respiratory compensation thresholds (LT. RCT). Respiratory gases were monitored during the exercise and blood samples were obtained at 1-minute intervals for determinations of lactate and PaCO2 levels. VA was determined by the modified alveolar gas equation. VA increased in a biphasic manner in relation to the increase in oxygen uptake (VO2), and Vo2 at the deflection point of the radio of VA to VO2 was highly correlated with the LT(r=0.92). VD also increased in a biphasic manner in relation to the increase in VOs+ and VO2 at the deflection point of the ratio of VD to VOs was correlated with VOw at the RCT (r=0.99). The slope of VD-VO2 relation above the RCT point was gerater in patients with MI and it was inversely related to peak VO2. Thus, the biphasic VA-VO2 relation was related to lactate production of exercising muscle, while the biphasic VD-VO2 relation was related to hyperventilation both in patients with MI and control subjects, and the enhanced response of VD above the RCT pointo in patients with MI was associated with lowered exercise tolerance and might be explained by hyperventilation and lower lung perfusion.
- 日本運動生理学会の論文
- 2000-02-00
著者
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Ajisaka Ryuichi
筑波大学 人間総合科学研究科スポーツ医学
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Yamaguchi Iwao
Cardiology Department Of Internal Medicine University Of Tsukuba Graduate School Of Comprehensive Hu
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Toyama Masahiro
Cardiology Department Of Internal Medicine University Of Tsukuba Graduate School Of Comprehensive Hu
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Ajisaka Ryuichi
Institute Of Clinical Medicine University Of Tsukuba
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Watanebe Shigeyuki
Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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