Assessment of Arterial Stiffness Index as a Clinical Parameter for Atherosclerotic Coronary Artery Disease
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概要
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Background The aim of the present study was to assess the feasibility and usefulness of the arterial stiffness index (ASI) measured non-invasively by computerized oscillometry and by comparing it with the pulse wave velocity (PWV). Methods and Results The study group comprised 60 consutive patients who underwent coronary angiography and whose aorto-femoral PWV were obtained with a Judkins catheter. The ASI was obtained using Cardio Vision^[○!R] MS-2000 (IMDP, Las Vegas, NV, USA) : (i) baseline (ASI-B); (ii) hyperemia induced by compression of the arm with cuff pressure for 5min (ASI-H); and (iii) sublingual nitroglycerin (ASI-N). In total, 34 patients had significant coronary artery disease (CAD). The PWV and all ASI were higher in patients with CAD than in those without CAD (ASI-B, 85.9±57.8 vs 48.2±24.5, p=0.001; ASI-H, 98.1±49.8 vs 48.1±21.3, p<0.01; ASI-N, 66.7±55.7 vs 33.2±27.9, p=0.002). However, only ASI-B and ASI-H were positively correlated to the PWV (ASI-B, r=0.27, p=0.03; ASI-H, r=0.49, p=0.001; ASI-N, r=0.19, p=0.16). The ASI was increased after hyperemia in patients with CAD (ASI-H, 85.9±57.8 to 98.1±49.8, p=0.01), but not in patients without CAD (ASI-H, 48.2±24.5 to 48.1±21.3, p>0.01). After adjusting their age, only ASI-H was correlated to the presence of CAD (r=0.33, p<0.01). Conclusions It is feasible and useful to use the ASI for detection of atherosclerotic coronary disease. The findings of ASI-H suggests that in addition to stiffening of the arterial wall itself, the impairment of flow mediated vasodilation, because of endothelial dysfunction, further increases the arterial stiffness.
- 社団法人日本循環器学会の論文
- 2005-09-20
著者
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Park Chang
Cardiovascular Center Korea University Guro Hospital
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Lim Hong
Cardiovascular Center Korea University Guro Hospital
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Ro Young
Korea University Medical Center
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Lim Hong
Division Of Cardiology Cardiovascular Center
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Shin Sung
Korea University Hospital
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Shin Sung
Department Of Cardiology Cardiovascular Center Korea University Hospital
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Park Seong
Division Of Cardiology Department Of Internal Medicine Korea University Medical College
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Ro Young
Department of Cardiology, Sejong General Hospital
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Seo Hong
Division of Cardiology, Department of Internal Medicine, Korea University Medical college
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Shin Sung
Division of Cardiology, Department of Internal Medicine, Korea University Medical college
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Park Chang
Division of Cardiology, Department of Internal Medicine, Korea University Medical college
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Oh Dong
Division of Cardiology, Department of Internal Medicine, Korea University Medical college
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Ro Young
Division of Cardiology, Department of Internal Medicine, Korea University Medical college
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Ro Young
Department Of Cardiology Cardiovascular Center Korea University Hospital
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Park Chang
Division Of Applied Biological Chemistry Graduate School Of Agriculture And Biological Sciences Osak
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