Lipase-Catalyzed Preparation of S-Propranolol in Presence of Hydroxypropyl β-Cyclodextrins(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
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概要
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A simple method for the preparation of S-propranolol catalyzed by a Rhizopus niveus lipase in an aqueous medium is described. Hydroxypropyl-β-cyclodextrin was used for the first time to increase the solubility of (R, S)-O-butyryl propranolol thus permitting the reaction to be carried out in water. The formation of an inclusion complex between (R, S)-O-butyryl propranolol and hydroxypropyl-β-cyclodextrin was studied and a stoichiometry of 1:1 was determined. The influences of the hydroxypropyl-β-cyclodextrin concentration, pH and percentage of ethanol on the enzymatic activity were also investigated. Under the conditions presented in this paper, values of ee_s of 90% and E=48 were obtained.
- 公益社団法人日本生物工学会の論文
- 2005-10-25
著者
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Francisco Garcia
Departamento De Bioquimicay Biologia Molecular-a Facultad De Veterinaria Universidad De Murcia
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Rizette Avila
Departamento De Bioquimicay Biologia Molecular-a Facultad De Veterinaria Universidad De Murcia
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Manuela Perez
Departamento de Bioquimicay Biologia Molecular-A, Facultad de Veterinaria, Universidad de Murcia
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Manuela Perez
Departamento De Bioquimicay Biologia Molecular-a Facultad De Veterinaria Universidad De Murcia
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Avila-Gonzalez Rizette
Departamento de Bioquimicay Biologia Molecular-A, Facultad de Veterinaria, Universidad de Murcia
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Perez-Gilabert Manuela
Departamento de Bioquimicay Biologia Molecular-A, Facultad de Veterinaria, Universidad de Murcia
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Garcia-Carmona Francisco
Departamento de Bioquimicay Biologia Molecular-A, Facultad de Veterinaria, Universidad de Murcia
関連論文
- Use of reversed phase high pressure liquid cromatography for the physicochemical and thermodynamic characterization of oxyresveratrol/β-cyclodextrin complexes
- Lipase-Catalyzed Preparation of S-Propranolol in Presence of Hydroxypropyl β-Cyclodextrins(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)