Sex Steroids, Bone Turnover and Bone Mineral Density in Pre-, Peri-, and Postmenopausal Women
スポンサーリンク
概要
- 論文の詳細を見る
To examine 1) the relationships between endogenous androgens and bone mineral density (BMD), 2) the relationships between sex-hormone binding globulin (SHBG) and BMD, and 3) the associations of endogenous androgens and SHBG with biochemical markers of bone turnover, a cross-sectional study was carried out in 88 healthy pre-, peri-, and postmenopausal women aged 35 to 74. Measurements of BMDs at the ultradistal radius and ulna, and the distal radius (using DEXA), estrogens, androgens, deoxypyridinoline (D-Pyr) and intact bone gla protein (I-BGP) were performed. In the multivariate regression models testosterone (T) was positively correlated with BMD at the ultradistal radius and ulna in perimenopausal women, and was positively correlated with BMD at the ultradistal radius and ulna, and the distal radius in postmenopausal women. T was positively associated with I-BGP in premenopausal women (r=0.65, p<0.01), and negatively associated with D-Pyr in pre- (r=-0.53, p<0.05) and postmenopausal women (r=-0.49, p<0.001). On the other hand, SHBG was negatively correlated with BMD at the ultradistal radius and ulna, and the distal radius in pre- and postmenopausal women in the models. SHBG was positively related to D-Pyr in pre-(r=0.57, p<0.05) and postmenopausal women (r=0.41, p<0.01), and negatively related to I-BGP in postmenopausal women (r=-0.38, p<0.01). These findings suggest that endogenous androgens may exert positive influences on BMD, and that SHBG may have negative effects on BMD.
著者
関連論文
- Metastatic Gastric Cancer from Malignant Fibrous Histiocytoma : Report of a Case
- Recurrent Pancreatitis Caused by Ampullary Carcinoma and Minor Papilla Adenoma in Familial Polyposis : Report of a Case
- Signet-Ring Cell Carcinoma of the Ampulla of Vater : Report of a Case
- Neoplastic Endocrine Differentiation of Pancreatic Ductal Adenocarcinoma in a Metastatic Lymph Node : Report of a Case
- Intrahepatic Cholangiocarcinoma with Old Infestation of Schistosoma japonicum : Report of a Case
- Inflammatory Pseudotumor of the Liver Masquerading as Hepatocellular Carcinoma After a Hepatitis B Virus Infection : Report of a Case
- Gallbladder carcinoma with osteoclast-like giant cells
- Hepatic artery pseudoaneurysm associate with cholecystitis that ruptured into the gallbladder
- Pseudoaneurysm of the Cystic Artery Secondary to Cholecystitis as a Cause of Hemobilia : Report of a Case
- Life-threatening bleeding from postbulbar duodenal ulcer saved by emergency transcatheter arterial embolization
- Intraductal growth of a nonfunctioning endocrine tumor of the pancreas
- Granular Cell Tumor of the Breast Preoperatively Diagnosed by Fine-Needle Aspiration Cytology : Report of a Case
- Impacted Obturator Hernia Treated Successfully with a Kugel Repair : Report of Two Cases
- Perineal Hernia as a Rare Complication After Laparoscopic Abdominoperineal Resection : Report of a Case
- Sex Steroids, Bone Turnover and Bone Mineral Density in Pre-, Peri-, and Postmenopausal Women