Total Synthesis of 0231B, an Inhibitor of 3α-Hydroxysteroid Dehydrogenase Produced by Streptomyces sp. HKI0231(Organic Chemistry)
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概要
- 論文の詳細を見る
The new inhibitors of 3α-hydroxysteroid dehydrogenase, 0231A 1 and 0231B 2, have a unique benz [c, d] indol-3 (1H) -one structure in their molecules. In our advanced studies on indole chemistry, we have developed an efficient synthetic method for benz [c, d] indol-3 (1H) -one derivatives. We report here its application to the synthesis of 0231B in 10 steps (8.1% overall yield) from 6-methylindole 8 by introducing an acyl group into the 3-position of the indole nucleus, cyclization of the side chain at the 3-position to the 4-position and subsequent elimination of the phenyl group, and conjugate addition of the substituted phenyl group.
- 社団法人日本農芸化学会の論文
- 2003-03-23
著者
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Nakatsuka S
Gifu Univ. Gifu Jpn
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Nakatsuka Shin-ichi
The United Graduate School Of Agricultural Science Gifu University
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KOMODA Taichi
The United Graduate School of Agricultural Science, Gifu University
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SHINODA Yoshihiko
The United Graduate School of Agricultural Science, Gifu University
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Komoda Taichi
The United Graduate School Of Agricultural Science Gifu University
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Shinoda Y
The United Graduate School Of Agricultural Science Gifu University
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Shinoda Yoshihiko
The United Graduate School Of Agricultural Science Gifu University
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Komada Taichi
The United Graduate School of Agricultural Science, Gifu University
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