Synthetic Racemate and Enantiomers of Cytosporone E, a Metabolite of an Endophytic Fungus, Show Indistinguishably Weak Antimicrobial Activity(Organic Chemistry)

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概要

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• The racemate and the enantiomers of cytosporone E [3-heptyl-4,5,6-trihydroxyphthalide (1)], a metabolite of the endophytic fungus, CR200 (Cytospora sp.), were synthesized. The key steps were (i) Sharpless asymmetric dihydroxylation of an alkene (8) and (ii) HPLC separation of the enantiomers of terf-butyldimethylsilyl ether (12) on a chiral stationary phase. The racemate and enantiomers of cytosporone E showed only weak antimicrobial activity with no difference among them.

• 社団法人日本農芸化学会の論文
• 2003-12-23

著者

• Mori Kenji

  Glycosphingolipid Synthesis Group Laboratory For Immune Regulation Research Center For Allergy And I

• Ohzeki Tomoya

  Department Of Chemistry Graduate School Of Science Science University Of Tokyo

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