Kinetic Resolutions of Indan Derivatives Using Bacteria(Microbiology & Fermentation Technology)

概要

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Racemic indan derivatives have been resolved by the hydrolysis of amide bonds using Corynebacterium ammoniagenes IFO12612 to produce (S)-amine and (R)-amides. In the kinetic resolution of 1 (N-[2-(6-methoxyindan-l-yl)ethyl]acetamide), it was possible to run the reaction to 44% conversion on a 10-g scale, obtaining (S)-amine 4 ((S)-2-(6-methoxy-indan-1-yl)ethylamine) at > 99% enantiomeric excess (ee) and (R)-1 at 98% ee.
社団法人日本農芸化学会の論文
2002-02-23