New Aspects of Physiological and Pathophysiological Functions of Adenosine A_<2A> Receptor in Basal Ganglia

概要

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There is now growing interest in the functional role of adenosine A_<2A> receptors. Their distribution within the brain is restricted in the basal ganglia, particularly abundant in the striatum, which are thought to play a crucial role in the control of motor behavior. Indeed, newly developed A_<2A> receptor selective antagonists have a profound influence on motor functions, with anti-Parkinsonian activities in several animal models. Striatal spiny neurons serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. The GABA releasing projection neurons represent the A_<2A> receptor-mediated main target of adenosine. The GABAergic synaptic neurotransmission is regulated by adenosine via A_<2A> receptors on the presynaptic terminals. Blockade of this modulatory function by A_<2A> antagonists could repair striatopallidal abnormal neuronal activities provoked by striatal dopamine depletion in the Parkinsonian state. A_<2A> receptor antagonists provide a novel therapeutic potential for the treatment of Parkinson's disease.
社団法人日本農芸化学会の論文
2001-07-23