Structural Characterization and Immunomodulating Activity of a Complex Glucan from Spores of Ganoderma lucidum(Biochemistry & Molecular Biology)

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概要

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• A polysaccharide with a molecular weight of 1.26×10^5, obtained from the sporoderm-broken spores of Ganoderma lucidum, was purified by anion-exchange and gel-permeation chromatography. This polysaccharide had a strong effect on suppressing the antibody production and the Con A or LPS induced lymphocyte proliferation in mice. Chemically, the structure of the polysaccharide was identified by methylation analysis, 1 D, 2 D NMR and ESI-MS spectroscopic studies of the native one and of the oligosaccharide fragments generated by partial acid hydrolysis, Smith degradation, and acetolysis. It was concluded that the intact polysaccharide was a complex β-D-glucan consisting of a (1→6)-linked backbone chain, in which every other glucosyl residue was substituted at C-3 or C-4 with mono-, di- and trisaccharide branches.

• 社団法人日本農芸化学会の論文
• 2001-11-23

著者

• Bao Xingfeng

  Shanghai Institute Of Materia Medica Shanghai Institutes For Biological Sciences Chinese Academy Of

• FANG Jinian

  Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy o

• LI Xiaoyu

  Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy o

• Li Xiaoyu

  Shanghai Institute Of Materia Medica Shanghai Institutes For Biological Sciences Chinese Academy Of

• Fang Jinian

  Shanghai Institute Of Materia Medica Shanghai Institutes For Biological Sciences Chinese Academy Of

• Feng Jinian

  Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

関連論文

• Structural Characterization and Immunomodulating Activity of a Complex Glucan from Spores of Ganoderma lucidum(Biochemistry & Molecular Biology)

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