Increased Stability of PEG-PPG Conjugated Human Urokinase against Autolysis

概要

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Human urokinase (UK) was easily degraded during the incubation at 37℃ in a time-dependent manner. The degradation was also observed in the presence of trypsin inhibitors, suggesting that UK was not degraded by exogeneous trypsin-like serine protease but by autolysis. In this cases, the A-chain of UK was selectively degraded. Polyethylene glycol-polypropylene glycol conjugated urokinase (PEG-PPG-UK) was not degraded after prolonged incubation at 37℃. These results demonstrated that PEG-PPG modification completely blocked the degradation of UK by autolysis.
社団法人日本農芸化学会の論文
1997-01-23