Effects of Antiplatelet Agents on Subacute Thrombosis and Restenosis After Successful Coronary Stenting : A Randomized Comparison of Ticlopidine and Cilostazol
スポンサーリンク
概要
- 論文の詳細を見る
Background A prospective randomized study compared the preventive effects of ticlopidine plus aspirin therapy versus cilostazol plus aspirin therapy on subacute thrombosis (SAT) and restenosis after coronary stenting. Methods and Results After successful stenting of 327 coronary lesions in 282 consecutive patients, the patients were randomized to receive ticlopidine (200mg/day) or cilostazol (200mg/day). Aspirin (81mg/day) was administered concomitantly in both groups. SAT occurred in 1 patient in the ticlopidine group (0.7%) and in 8 patients in the cilostazol group (5.6%, p=0.037). Based on follow-up angiography, restenosis occurred in 30 patients (23.3%) in the ticlopidine group and 35 patients (26.9%) in the cilostazol group (NS). The late loss was significantly smaller in the cilostazol group than the ticlopidine group (1.08±0.95 mm vs 0.78±0.93 mm, respectively, p=0.037). No significant differences between the 2 groups were observed with respect to the rates of total death, non-fatal cardiovascular events, or bleeding complications. Conclusion The ticlopidine group showed significantly less SAT after stenting compared with the cilostazol group. After 6 months of treatment, the inhibition of neointimal proliferation was greater in the cilostazol group than in the ticlopidine group, but the prevention ofrestenosis was not confirmed.
- 社団法人日本循環器学会の論文
- 2004-06-20
著者
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Kurabayashi Masahiko
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine
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Adachi Hitoshi
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Taniguchi Koichi
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Hoshizaki Hiroshi
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Suguta Masahiko
Department Of Dermatology Gunma University Graduate School Of Medicine
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Saga Makoto
Department Of Cardiovasucular Medicine Fukui University Hospital
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Kurabayashi Masahiko
Department Of Medicine And Biological Science Gunma University Graduate School Of Medicine
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Ohshima Shigeru
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Ohshima Shigeru
Gunma Prefectural Cardiovascular Center
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Sekiguchi Makoto
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Suguta Masahiko
Department Of Cardiovasucular Medicine Fukui University Hospital
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Sekiguchi Makoto
Department Of Cardiovasucular Medicine Fukui University Hospital
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Sekiguchi Makoto
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Kurabayashi Masahiko
Department Of Cardiology Kanazawa Medical University
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Taniguchi Koichi
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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