Progressive Nature of Paroxysmal Atrial Fibrillation : Observations From a 14-Year Follow-up Study
スポンサーリンク
概要
- 論文の詳細を見る
Background Atrial fibrillation (AF) is believed to occur first as paroxysmal, then be gradually perpetuated, and finally become chronic as the end result. However, this presumed clinical course has not been well confirmed. Methods and Results The clinical course of recurrent paroxysmal AF (PAF) from its onset was examined in 171 patients (mean follow-up period: 14.1±8.1 years). This study population consisted of patients with no structural heart disease (n=88), ischemic heart disease (n=28), dilated or hypertrophic cardiomyopathy (n=17), valvular heart disease (n=35) or other cardiac diseases. The mean age at the onset of AF was 58.3±11.8 years old. During the mean follow-up period of 14.1 years, PAF eventually developed into its chronic form in 132 patients under conventional antiarrhythmic therapy (77.2%, 5.5% of patients per year). The independent factors for early development into chronic AF were aging (hazard ratio (HR) 1.27 per 10 years, 95% confidence interval (CI) 1.06-1.47)), dilated left atrium (HR 1.39 per 10mm, 95% CI 1.11-1.69), myocardial infarction (HR 2.33, 95% CI 1.13^.81), and valvular diseases (HR 2.29, 95% CI 1.22-4.30). Conclusions The present long-term observations definitely and quantitatively revealed the progressive nature of PAF.
- 社団法人日本循環器学会の論文
- 2004-05-20
著者
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Yajima Toshimi
The Cardiovascular Institute Department Of Medicine Keio University School Of Medicine
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Sagara Kouichi
The Cardiovascular Institute Hospital
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Fu Long-Tai
The Cardiovascular Institute Hospital
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Iinuma Hiroyuki
The Cardiovascular Institute
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Long-Tai Fu
The Cardiovascular Institute
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YAMASHITA Takeshi
The Cardiovascular Institute
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Sagara Kouichi
The Cardiovascular Institute
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Kijima T
Department Of Cardiology Tokyo Women's Medical University
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Kato Takeshi
The First Department Of Internal Medicine Nippon Medical School
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Fu Long-tai
The Cardiovascular Institute
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Inoue Hiroki
Department Of Chemistry Faculty Of Science Kyushu University
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Kato Takeshi
The Cardiovascular Institute
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Fu Long
The Cardiovascular Institute
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Tanizaki Kohei
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
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Takahashi Yasuhiro
Division Of Cardiology Department Of Internal Medicine Nippon Medical School
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Sagara Kouichi
Cardiovascular Institute School Of Health And Sports Science Juntendo University
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SAKURADA Koji
The Cardiovascular Institute
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