Enzymatic Optical Resolution of N-Benzyl-3-pyrrolidinol

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概要

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• The enzymatic optical resolution of racemic N-benzyl-3-pyrrolidinol (2) was investigated. It was found that only (R)-2 was acetylated by the lipase Amano P in yields of 50% and 100%e.e. Remaining (S)-alcohol 2 could be chemically inverted to (R)-acetate 3. A continuous reaction in a column reactor could be also applied to this optical resolution. After concentrating the eluted solution, the residue was subjected to the inversion reaction to provide (R)-acetate 3 in an 83% yield and 91%e.e. from the racemate.

• 社団法人日本農芸化学会の論文
• 1995-07-23

著者

• Horiguchi Akira

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Mochida Ken-ichi

  Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

関連論文

• Enzymatic Synthesis of (S)-2-(6-Benzyloxy-2,5,7,8-tetramethyl-2-chromanyl) ethanol, Intermediate for the Synthesis of Vitamin E
• Enzymatic Optical Resolution of N-Benzyl-3-pyrrolidinol

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