Effects of Elevated Expression of the CYP51 (P450_<14DM>) Gene on the Sterol Contents of Saccharomyces cerevisiae

概要

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Lanosterol metabolism was elevated in yuast cells cultured both aerobically and semi-anaerobically by increased expression of ianosterol 14α-demethylase P450 (P450_<14DM> or CYP51). However, despite increases in the diene-intermediates of ergosterol biosynthesis, the ergosterol content was not affected. These results suggested that the levels of cellular sterols are controlled in at least two stages, and that the concomitant elevation of P450_<14DM> and ergostadienols desaturase (P450_<22DS>)is required to increase the cellular ergosterol content.
公益社団法人日本生物工学会の論文
1995-01-25