Aromatic Amino Acids Production by Analogue-resistant Mutants of Methylomonas methanolophila 6R : Microbial Production of Aromatic Amino Acids from Methanol (II)

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概要

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• A new methanol-utilizing strain, Methylomonas methanolophila 6R was treated with the mutagen N-methyl-N'-nitro-N-nitrosoguanidine (NTG), and mutants resistant to aromatic amino acid-analogues were selected. A mutant, strain E431,which was resistant to 1000μg/ml of β-2-thienylalanine, 1000μg/ml of 5-methyltryptophan and 1000μg/ml of 3-aminotyrosine produced 4000μg/ml of phenylalanine, 1100μg/ml of tyrosine and 200μg/mol of tryptophan in mineral salts-methanol medium supplemented with biotin and thiamine, as opposed to the wild type strain which produced 1μg/ml of tryptophan and 3-5μg/ml of tyrosine and phenylalanine.

• 公益社団法人日本生物工学会の論文
• 1977-10-25

著者

• Berglund Anders

  Department Of Microbiological Engineering Karolinska Institutet

• Unden Ake

  Department Of Microbiological Engineering Karolinska Institutet

• SUZUKI MASARU

  (Present address) Central Research Division, Takeda Chemical Industries, Ltd.,

• HEDEN CARL-GORAN

  Department of Microbiological Engineering, Karolinska Institutet

• Suzuki Masaru

  (present Address) Central Research Division Takeda Chemical Industries Ltd.

• Heden Carl-goran

  Department Of Microbiological Engineering Karolinska Institutet

関連論文

• Aromatic Amino Acids Production by Analogue-resistant Mutants of Methylomonas methanolophila 6R : Microbial Production of Aromatic Amino Acids from Methanol (II)
• Identification of a New Methanol-utilizing Bacterium and Its Characteristic Response to Some Chemicals : Microbial Production of Aromatic Amino Acids from Methanol (I)

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