Analysis of the Antigen Recognition Sites of Anti-Methamphetamine Monoclonal Antibodies(II) : Unique Feature of MA-3 Antibody

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概要

• 論文の詳細を見る

• A monoclonal antibody against methamphetamine(MA-3 mAb) was found to be strongly bound to ephedrine. This feature was quite different from that of other fourteen mAbs against MA. Analyses of cDNA sequence and steric conformation by molecular modeling revealed that one hydrophilic pocket was generated in the heavy chain of MA-3 mAb involving CDRH-1 and CDRH-2. Asn33, Asn35, Asn50 and Asp52 were the main components of the unique pocket capable of binding to the hydroxyl group of ephedrine.

• 社団法人日本生物工学会の論文
• 2000-05-25

著者

• Hifumi E

  School Of Biosciences Hiroshima Prefectural University:crest Of Japan Science And Technology Agency

• Hifumi Emi

  Presto Japan Sci. And Technol. Corp. (jst) Kawaguchi Saitama 332-0012 Jpn

• Uda T

  Hiroshima Prefectural University School Of Biosciences

• Uda T

  School Of Biosciences Hiroshima Prefectural University:crest Of Japan Science And Technology Agency

• Uda Taizo

  School Of Biosciences Hiroshima Prefectural University

• Uda Taizo

  School Of Bioresources Hiroshima Prefectural University

• Uda T

  Hiroshima Prefectural Univ. Hiroshima Jpn

• HIFUMI EMI

  School of Biosciences, Hiroshima Prefectural University

• Itoh Takafumi

  Div. Of Appl. Life Sci. Grad. Sch. Of Agriculture Kyoto Univ.

• ISHIMARU Masanori

  Peptide Institute Inc., Protein Research Foundation

• Itoh Takuzi

  School Of Biosciences Hiroshima Prefectural University

• Ishimaru Masanori

  School Of Biosciences Hiroshima Prefectural University

• MORIKAWA KEIKO

  School of Biosciences, Hiroshima Prefectural University

• Hifumi Emi

  School Of Biosciences Hiroshima Prefectural University

• Morikawa Keiko

  School Of Biosciences Hiroshima Prefectural University

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