Functional and Structural Roles of Constituent Amino Acid Residues of Bovine Pancreatic Ribonuclease A
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概要
- 論文の詳細を見る
In protein engineering, wherein the goal is desirable function and high conformational stability, the characteristics of each constituent amino acid residue are important, in terms of the overall characteristics of the target protein. Bovine pancreatic riobonuclease A (RNase A) is, historically, one of the most intensively analyzed proteins, and a considerable amount of information is available on amino acid-level information. Such data would serve to aid the understanding of relationships between the distribution of various amino acid residues in the protein molecule and the unique structure and/or functions of RNase A. This review summarizes the thus-far clarified roles of 38 of the total 124 amino acid residues which comprise RNase A, with respect to protein function, stability, and folding.
- 公益社団法人日本生物工学会の論文
- 2001-08-25
著者
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Chatani Eri
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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HAYASHI Rikimaru
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University
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Hayashi Rikimaru
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
関連論文
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- Role of Carbohydrate Moiety in Carboxypeptidase Y : Structural Study of Mutant Enzyme Lacking Carbohydrate Moiety
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