運動と酸化ストレス

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Strenuous physical exercise is well known to impose oxidative stress on the body due to the generation of reactive oxygen species(ROS). There are a number of potential sources for the increased generation of ROS during and after exercise ; especially, mitochondrial electron transport system, cytoplasmic xanthine-xanthine oxidase system, and neutrophils are important. Acute exercise increases the levels of lipid peroxidation, and enhances oxidative modification of proteins and DNA. Although acute exercise also can increase some of antioxidant enzymes activities in active tissues, such an increased level of antioxidant enzymes seems not to be sufficient to cope with an increased generation of ROS. On the other hand, growing evidence has indicated that endurance training improves the resistance of active tissues to exercise-induced oxidative stress. Further, strenuous exercise causes oxidative damage in active tissues through the activation of an inflammatory pathway, including the production of cytokines, like IL-1 and TNF, and neutrophils activation, whereas endurance training reduces such a response to strenuous exercise. Moreover, regular exercise reduces the incidence of cancer and increases life expectancy, probably due to the up-regualtion of the antioxidant enzyme system and the DNA repair process. Further studies, however, are required to establish a proper regular exercise protocol and/or an antioxidant supplementation for minimizing oxidative damage and improving quality of life.
日本運動生理学会の論文
2001-10-31

運動と酸化ストレス

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