乳酸輸送担体MCTの発現と乳酸の代謝との関係

概要

論文の詳細を見る
Transport of lactate through plasma membrane, that had been thought to be free diffusion, is now revealed to be carrier mediated process. MCTs(Monocarboxylate Transporters) are the transporters of lactate and other monocarboxylates such as pyruvate. MCT1 is the first MCT cloned in 1994. MCT1 is rich in slow type muscle fibers and myocardium. The expression of MCT1 is related to the muscle oxidative capacity and to the uptake of lactate into the skeletal muscles and heart. Endurace training can increase the amount of MCT1 in the muscle and heart. MCT1 is possibly located not only at the plasma membrane but also at the mitochondrial membrane. On the other hand, MCT4 is rich in fast type muscle fibers. There is a reasonable concordance between the expression of MCT4 and the glycolytic capacity in the skeletal muscle. MCT4 is thought to relate mainly to extrusion of lactate out of glycolytic muscles. Therefore, MCTs particularly MCT1 and MCT4 play important roles for influx and extrusion of lactate into and out of skeletal muscle and other tissues during and after exercise. Further studies are required to elucidate the regulation of the expression of MCTs and the effect of changes in the expression of MCTs on lactate metabolism during and after exercise.
日本運動生理学会の論文
2000-09-30