Production of D-β-Hydroxyisobutyric Acid from Isobutyric Acid by Candida rugosa

概要

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Production of D-β-hydroxyisobutyric acid (D-HIBA) from isobutyric acid (IBA) was investigated using Candida rugosa IFO 0750. Cell growth and D-HIBA production decreased as the substrate concentration increased. A considerable degradation of D-HIBA was observed when the substrate, IBA, was depleted in the medium. Specific production rate of D-HIBA increased as glucose concentration decreased, while the conversioin yield of IBA to D-HIBA showed an opposite trend. With a controlled feeding of IBA and glucose, a high titer of D-HIBA (100 g/l) could be obtained by a fed-batch cultivation of Candida rugosa.
社団法人日本生物工学会の論文
1996-01-25