Chiral Bio-Resolution of Racemic Indene Oxide by Fungal Epoxide Hydrolases
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概要
- 論文の詳細を見る
Eighty fungal strains were evaluated for their production of an epoxide hydorlase capable of catalyzing the kinetic resolution of racemic indene oxide into 1(S), 2(R) indene oxide. This screen identified Diplodia gossipina ATCC 16391 as the best catalyst. Process development studies of this bio-resolution demonstrated that the optical purity of the 1(S), 2(R) indene oxide produced was dependent upon pH and substrate concentration. A shake-flask-scale bio-resolution process supported the prodecution of preparative quantities of optically pure (ee=100%) 1(S), 2(R) indene oxide.
- 社団法人日本生物工学会の論文
- 1995-09-25
著者
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Roberge Ghristopher
Merck Research Laboratories
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Senanayake Chris
Merck Research Laboratories
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GREASHAM RANDOLPH
Merck Research Laboratories
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ZHANG JINYOU
Merck Research Laboratories
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REDDY JAY
Merck Research Laboratories
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CHRTRAIN MICHEL
Merck Research Laboratories
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- Bioconversion of Indene to cis(1S, 2R)Indandiol and trans(1R, 2R)Indandiol by Rhodococcus Species
- Chiral Bio-Resolution of Racemic Indene Oxide by Fungal Epoxide Hydrolases
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