Non-Fragmenting Variants of Streptomyces Hyphae Have Enhanced Activity of an Enzyme (Phospho-N-Acetylmuramyl Pentapeptide Translocase) in Peptidoglycan Biosynthesis

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概要

• 論文の詳細を見る

• The repeated use of an enrichment technique for establishment of antibiotic production in liquid culture, where previously production had only been seen on agar, resulted in the slection of stable strain variants with enhanced resistance to fragmentation. The variant was more resistant to tunicamycin, an inhibitor of peptidoglycan biosynthesis, than the wild-type. When peptidoglycan synthesis was compared in the variant and the wild-type strains of one of the isolates, enhanced activity of the enzyme : phospho-N-acetylmuramyl pentapeptide translocase (which catalyses the first membrane bound reaction of cell wall synthesis) was found in the fragmentation-resistant form.

• 公益社団法人日本生物工学会の論文
• 1995-03-25

著者

• PICKUP KAREN

  Microbial Physiology Group, School of Biological Sciences, University of Surrey

• Bushell Michael

  Microbial Physiology Group School Of Biological Sciences University Of Surrey

• Pickup Karen

  Microbial Physiology Group School Of Biological Sciences University Of Surrey : (present Adress)gum Health Department Unilever Research Port Sunlight Laboratory

関連論文

• A Method for Increasing the Success Rate of Duplicating Antibiotic Activity in Agar and Liquid Cultures of Streptomyces Isolates in New Antibiotic Screens
• Non-Fragmenting Variants of Streptomyces Hyphae Have Enhanced Activity of an Enzyme (Phospho-N-Acetylmuramyl Pentapeptide Translocase) in Peptidoglycan Biosynthesis

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