Features of Distamycin Preferential Binding Sites on Natural DNA Predicted Using Differential Scanning Calorimetry

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概要

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• The interaction of distamycin with ColE1 DNA was examined by using differential scanning calorimetry (DSC) taking the helix-coil transition theory of DNA into consideration. Our results here strongly indicate that the affinity of distamycin to DNA, at a low distamycin concentration, depends highly on the DNA sequence, and preferential binding occurs to the sites of four to six successive A-T pairs having two or more successive G-C pairs on both their ends.

• 社団法人日本農芸化学会の論文
• 2001-05-23

著者

• Kawai Yoshio

  Faculty Of Life Sciences Toyo University

• Maeda Yoshimi

  College Of Science And Engineering Iwaki Meisei University

• UETA Hiroyuki

  College of Science and Engineering, Iwaki Meisei University

• Ueta Hiroyuki

  College Of Science And Engineering Iwaki Meisei University

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• Studies on 5-Lipoxygenase Inhibitors. I. Synthesis and 5-Lipoxygenase-Inhibitory Activity of Novel Hydroxamic Acid Derivatives
• Features of Distamycin Preferential Binding Sites on Natural DNA Predicted Using Differential Scanning Calorimetry

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