Facile Synthesis of (R)-4-Mercaptopyrrolidine-2-thione from L-Aspartic Acid

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概要

• 論文の詳細を見る

• An SN2-type of substitution of (S)-bromide 4,which had been prepared from L-aspartic acid, with potassium thiobenzoate provided (R)-benzoylthio derivative 5 with complete inversion of the configuration. Compound 5 was converted, via iodide 6c, to (R)-4-amino-3-benzoylthiobutyric acid 8b. (R)-4-Mercapto pyrrolidine-2-thione 1 was readily obtained from 8b through cyclization with acetic anhydride, with Lawesson's reagent and facile removal of the S-benzoyl group with sodium methoxide.

• 社団法人日本農芸化学会の論文
• 2001-04-23

著者

• Seki Masahiko

  Product & Technology Development Laboratory Tanabe Seiyaku Co.ltd.

• Seki Masahiko

  Product & Technology Development Laboratory Tanabe Seiyaku Co. Ltd.

• SHIMIZU Toshiaki

  Product & Technology Development Laboratory, Tanabe Seiyaku Co.Ltd.

• Shimizu Toshiaki

  Product & Technology Development Laboratory Tanabe Seiyaku Co.ltd.

関連論文

• Facile Synthesis of (R)-4-Mercaptopyrrolidine-2-thione from L-Aspartic Acid
• An Efficient Synthesis of C_2-Symmetric Chiral Binaphthyl Ketone Catalysts

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