Inhibition of Fungal Cell Wall Synthesizing Enzymes by trans-Cinnamaldehyde

スポンサーリンク

概要

• 論文の詳細を見る

• This study examined the inhibitory effects of transcinnamaldehyde (CA), an aromatic aldehyde derived from Cinnamomi Cortex, on Saccharomyces cerevisiae cell wall synthesizing enzymes in vitro. This compound was found to be a noncompetitive inhibitor of β-(1,3)-glucan synthase and a mixed inhibitor of chitin synthase 1 with 50% inhibitory concentrations (IC_<50>) of 0.84 and 1.44 mM, respectively. Chitin synthases 2 and 3 were less sensitive than chitin synthase 1 to CA. CA can be useful as a model compound of cell wall inhibitors for the development of effective antifungal agents.

• 社団法人日本農芸化学会の論文
• 2000-05-23

著者

• Rhee Youngha

  Department Of Microbiology College Of Natural Sciences Chungnam National University

• Bang Kyuho

  Department Of Microbiology College Of Natural Sciences Chungnam National University

• LEE DongWon

  Department of Microbiology, College of Natural Sciences, Chungnam National University

• PARK HeeMoon

  Department of Microbiology, College of Natural Sciences, Chungnam National University

• Lee Dongwon

  Department Of Microbiology College Of Natural Sciences Chungnam National University

• Park Heemoon

  Department Of Microbiology College Of Natural Sciences Chungnam National University

• Bang Kyu-Ho

  Department of Microbiology, College of Natural Sciences, Chungnam National University

• Lee Dong-Won

  Department of Microbiology, College of Natural Sciences, Chungnam National University

• Park Hee-Moon

  Department of Microbiology, College of Natural Sciences, Chungnam National University

関連論文

• Inhibition of Fungal Cell Wall Synthesizing Enzymes by trans-Cinnamaldehyde

スポンサーリンク