Inhibition of Radiation-Induced Lipid Peroxidation by Tetrahydrocurcumin : Possible Mechanisms by Pulse Radiolysis
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概要
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The antioxidant property of tetrahydrocurcumin (THC), a reduced derivative of curcumin, was examined by its ability to inhibit radiation-induced lipid peroxidation in rat liver microsomes and compared with curcumin. The lipid peroxidation caused by irradiation of N_2O-purged and aerated buffered aqueous solutions was found to be inhibited by THC in a dose-and concentration-dependent manner. In order to understand the actual reaction mechanisms involved in the inhibition process, pulse radiolysis investigation of THC with radiolytically produced radicals like hydroxyl, model peroxyl radicals, and azide radicals were done and the transients were detected by kinetic spectrophotometry. The reaction of THC with hydroxyl and azide radicals gave rise to transient absorption in the region 200-400 nm with two peaks at 310 nm and 390 nm. From the spectral properties and kinetics of these radicals, a suitable mechanism is discussed to explain the antioxidant actions of THC.
- 社団法人日本農芸化学会の論文
- 2000-03-23
著者
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Venkatesan Parameswaran
College Of Pharmaceutical Sciences Kasturba Medical College
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KHOPDE SujataM.
Radiation Chemistry and Chemical Dynamics Division
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PRIYADARSINIK Indira
Radiation Chemistry and Chemical Dynamics Division
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GUHA ShambhuNath
Radiation Chemistry and Chemical Dynamics Division
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SATAV JagganathG.
Radiation Biology Division, Bhabha Atomic Research Centre, Trombay
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RAO MysoreN.Aswathanarana
College of Pharmaceutical Sciences, Kasturba Medical College
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Rao Mysoren.aswathanarana
College Of Pharmaceutical Sciences Kasturba Medical College
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Satav Jagganathg.
Radiation Biology Division Bhabha Atomic Research Centre Trombay
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Khopde Sujata
Radiation Chemistry and Chemical Dynamics Division
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Priyadarsini K.Indira
Radiation Chemistry and Chemical Dynamics Division
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Guha Shambhu
Radiation Chemistry and Chemical Dynamics Division