Antibacterial Activities of Cryptotanshinone and Dihydrotanshinone I from a Medicinal Herb, Salvia miltiorrhiza Bunge

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概要

• 論文の詳細を見る

• Cryptotanshinone and dihydrotanshinone I, constituents of a medicinal plant, Salvia miltiorrhiza Bunge, had antibacterial activity against a broad range of Gram positive bacteria. These compounds generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was 2- to 8-fold more sensitive than a wild strain, and this hypersensitivity was reduced in the presence of dithiothreitol as an antioxidant. DNA, RNA, and protein syntheses in B. subtilis were nonselectively inhibited by these compounds. These results suggest that superoxide radicals are important in the antibacterial actions of the agents.

• 社団法人日本農芸化学会の論文
• 1999-12-23

著者

• Lee Sang-han

  Dapartment Of Microbiology College Of Natural Science Kyungpook National University

• Lee D‐s

  Inst. Physical And Chemical Res. Riken Hyogo Jpn

• Hong S‐d

  Dapartment Of Microbiology College Of Natural Science Kyungpook National University

• Noh Jae-geun

  Exotic Nano-material Laboratory The Institute Of Physical And Chemical Research (riken)

• LEE Dong-Sun

  Dapartment of Microbiology, College of Natural Science, Kyungpook National University

• HONG Soon-Duck

  Dapartment of Microbiology, College of Natural Science, Kyungpook National University

関連論文

• Antibacterial Activities of Cryptotanshinone and Dihydrotanshinone I from a Medicinal Herb, Salvia miltiorrhiza Bunge

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