Practical Preparation of K-252a from a Fermentation Solution

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概要

• 論文の詳細を見る

• We developed a practical preparation procedure for K-252a by methylating K-252b on an industrial scale. The water-insoluble K-252a, which was present in the cell mass, was converted to the water-soluble K-252b Na salt in an alkaline solution. The obtained K-252b was methylated with dimethylsulfate in the presence of potassium carbonate in dimethylacetamide. We have already used this method to manufacture 90 kg of K-252b from the fermentation broth, and regenerated 65 kg of K-252a from K-252b.

• 社団法人日本農芸化学会の論文
• 1998-08-23

著者

• NAGAMURA Satoru

  Kyowa Hakko Kogyo Co., Ltd., Tokyo Research Laboratories

• Nishimura Tetsuo

  Kyowa Hakko Kogyo Co. Ltd.

• Kino Mitsutaka

  Kyowa Hakko Kogyo Co. Ltd.

• Shono Kenzo

  Kyowa Hakko Kogyo Co. Ltd.

• Nagamura Satoru

  Kyowa Hakko Kogyo Co. Ltd.

関連論文

• Synthesis and Antitumor Activity of Duocarmycin Derivatives : Modification of Segment A of Duocarmycin B2
• Wagner-Meerwein Rearrangement of Duocarmycins
• Practical Preparation of K-252a from a Fermentation Solution

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