Processing and Secretion of Human Growth Hormone with an Artificial Signal Sequence

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概要

• 論文の詳細を見る

• We examined the secretion of human growth hormone in yeast cells with the artificial signal sequence L8LP, which is functional for human lysozyme secretion. The precursor was cleaved etliciently and the mature protein was secreted into the periplasmic space, but the protein aggregated. These results suggest that L8LP is also functional for human growth hormone. pl precipitation might be responsible for the aggregation.

• 社団法人日本農芸化学会の論文
• 1994-04-23

著者

• Yamamoto Yoshio

  Protein Engineering Research Institute

• Kohara Atuko

  Protein Engineering Research Institute

• KIKUCHI Masakazu

  Protein Engineering Research Institute

関連論文

• A Role of PDI in the Reductive Cleavage of Mixed Disulfides
• Processing and Secretion of Human Growth Hormone with an Artificial Signal Sequence

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