The Role of Cytochrome P-450_<sca> in Streptomyces : Interaction of Azole Compounds with Cytochrome P-450_<sca>

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概要

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• Azole compounds inhibited both hydroxylation catalyzed by cytochrome P-450_<sca> and the growth of Streptomyces carbophilus. The growth inhibition could be overcome by inducing cytochrome P-450_<sca> production in the cells. These results suggest that cytochrome P-450_<sca> has an intrinsic substrate as well as xenobiotics. Such a P-450 that has both substrates seems to be unique among the prokaryotic P-450 enzymes.

• 社団法人日本農芸化学会の論文
• 1993-10-23

著者

• Serizawa Nobufusa

  Fermentation Research Laboratories Sankyo Co. Ltd.

• Matsuoka Tatsuji

  Fermentation Research Laboratories, Sankyo Co., Ltd.,

関連論文

• Secretion and Overproduction of Carboxypeptidase Y by a Saccharomyces cerevisiae ssl1 Mutant Strain
• The Role of Cytochrome P-450_ in Streptomyces : Interaction of Azole Compounds with Cytochrome P-450_
• Microbial Transformation of ML-236B (Compactin) to M3, a Mammalian Metabolite of ML-236B

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