Effects of Nicorandil on Endogenous Fibrinolytic Capacity in Patients With Coronary Artery Disease
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概要
- 論文の詳細を見る
Background Nicorandil is a hybrid-type anti-anginal drug that combines a KATP channel opener and a nitric oxide donor. Recently the IONA study reported that nicorandil improves the prognosis of patients with stable angina pectoris. Methods and Results To examine the effects of nicorandil on endogenous fibrinolysis, plasma concentrations of tissue-type plasminogen activator (t-PA) antigen, type-1 plasminogen activator inhibitor (PAI-1) antigen and PAI activity were measured in consecutive 11 patients (7 men and 4 women, mean age 63 years, ranges 41-84 years) with coronary artery disease. Nicorandil (15 mg/day) was administered orally to each patient for 2 weeks. Venous blood samples were obtained from each patient before and after the administration of the drug in the early morning before eating. There were no significant changes in the plasma concentrations of t-PA (12.4±1.9 to 9.8±1.5) or PAI-1 (26.3±3.9 to 21.5±4.9) antigens (ng/ml, mean±SEM) before and after nicorandil administration. On the other hand, the plasma activity of PAI (IU/ml, mean±SEM) decreased significantly after the treatment (12.9±3.2 to 5.6±1.9, p=0.039). Conclusions It is well known that PAI activity determines the whole fibrinolytic capacity and oral administration of nicorandil decreased PAI activity in patients with coronary artery disease. This finding suggests that nicorandil improves the fibrinolytic capacity and may reduce the risk of coronary thrombus formation in such patients.
- 社団法人日本循環器学会の論文
- 2004-02-20
著者
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Yoshimura Michihiro
Department of Caldiology Jikei University School of Medisine
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Sakamoto Tomohiro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Kaikita Koichi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Sugiyama Seigo
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Kojima Sunao
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto Uinversity
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MIYAMOTO Shinzo
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Miyamoto Shinzo
Division Of Cardiology Kumamoto Central Hospital
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Satoh Toru
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Miyamoto Shinzo
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Ogawa Hisao
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
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Sakamoto Mieko
Division Of Cardiology Kumamoto Central Hospital
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SAKAMOTO Tomohiro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University
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Sakamoto Tomohiro
Department of Cardiology, Saiseikai Kumamoto Hospital, Japan
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