Prolongation of LAS_40 (Duration of the Low Amplitude Electric Potential Component (<40★V) of the Terminal Portion of the QRS) Induced by Isoproterenol in 11 Patients With Brugada Syndrome

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概要

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• The electrophysiological mechanism of Brugada syndrome is unclear, but transmural dispersion of repolarization in the right ventricle is believed to be the most likely mechanism. On the other hand, the presence of a conduction delay region is considered to be related to the occurrence of ventricular fibrillation; that is, a relationship between the presence of a ventricular late potential (LP) and arrhythmogenic right ventricular cardiomyopathy. In this study, the LP from signal-averaged electrocardiography during isoproterenol (ISP) administration in patients with Brugada syndrome is discussed. The subjects were 11 patients with Brugada syndrome and 6 healthy individuals. In all subjects, the total filtered QRS duration (fQRS), root mean square voltage of the 40ms terminal portion of the QRS (RMS_40), duration of the low amplitude electric potential component (40★V) of the terminal portion of the QRS (LAS_40), and time duration of the fQRS-LAS_40 difference were compared between when ISP was prescribed and when it was not. During ISP administration, a peculiar response, which resulted in an LAS_40 prolongation, was observed in the patients with Brugada syndrome. With ISP, the fQRS remained unchanged, but the RMS_40 and the fQRS-LAS_40 decreased. Consequently another 3 patients with a positive LP were diagnosed using the ordinary standard because of the administration of ISP. We believe that the low-amplitude component was unmasked by shortening of the high-amplitude component. In patients with Brugada syndrome, a conduction delay in the ventricle may be present and may be related to the occurrence of ventricular fibrillation.

• 社団法人日本循環器学会の論文
• 2002-11-20

著者

• Sakurai Tsuneharu

  Clinical Lab . St. Marianna Unviersity School Of Medicine

• Takagi Akihiko

  Asao Hospital

• Nakazawa Kiyoshi

  Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine

• Sakurai Tsuneharu

  Division of Laboratory Medicine, St. Marianna University Hospital

• Takagi Akihiko

  Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine

• Miyake Fumihiko

  Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine

• Miyake Fumihiko

  Division Of Cardiology St. Marianna University School Of Medicine

• Miyake Fumihiko

  2nd Department Of Medicine St.marianna University School Of Medicine

• Miyake Fumihiko

  St. Marianna University School Of Medicine Division Of Internal Medicine

• Nanke Toshihiko

  Division Of Cardiology Department Of Internal Medicine St.mariannna University School Of Medicine

• Nanke Toshihiko

  Department Of Cardiology St. Marianna University School Of Medicine

• Nanke Toshihiko

  Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine

• Nakamura Toshika

  Division Of Cardiology Department Of Internal Medicine St.mariannna University School Of Medicine

• Sano Toshio

  Department Of Cardiology Yokohama Minami Kyosai Hospital

• Nakazawa Kiyoshi

  Division Of Cardiology St. Marianna University School Of Medicine

• Nakamura Toshika

  The 2nd Dept. Of Internal Med. St.marianna University. School Of Med.

• Miyake Fumihiko

  Division Of Cardiology Department Of Internal Medicine St Marianna University School Of Medicine

• Takagi Akihiko

  Division of Analytical Chemistry of Medicines, Showa Pharmaceutical University

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