Lipid Peroxidation May Predict Restenosis After Coronary Balloon Angioplasty
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概要
- 論文の詳細を見る
The present study assessed whether lipid peroxidation in plasma might predict restenosis after coronary balloon angioplasty. A total of 87 patients, who had undergone successful coronary balloon angioplasty using standard techniques, were enrolled. Fasting blood samples before the intervention were measured for plasma levels of thiobarbituric acid reactive substances (TBARS, an indicator of lipid peroxidation). Angiography was carried out before and 15min after angioplasty, and at follow-up (4 months after angioplasty), and evaluated using a quantitative approach. There were 23 patients with restenosis (group R) and 64 patients without restenosis (group N) after coronary balloon angioplasty. The plasma TBARS level (mean±SEM) of 4.3±0. lμmol/L in group R was significantly higher than that of 3.2±0.1μmol/L in group N (p<0.01). There were no significant differences in other parameters, including plasma lipid levels, between the 2 groups. The plasma level of TBARS positively correlated with lumen loss of the coronary artery at the time of follow-up angiography (r=0.57, p<0.01). Our results suggest that oxidative stress contributes to restenosis and indicate that an elevated plasma level of TBARS may be a reliable predictor of restenosis. (Jpn Circ J 2001; 65: 495-499)
- 2001-05-20
著者
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Kanashiro Masaaki
Department Of Cardiology Yokkaichi Municipal Hospital
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Ichimiya Satoshi
Department Of Cardiology Yokkaichi Municipal Hospital
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Moriyama T
Osaka Univ. Osaka Jpn
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Mizuno Tomofumi
愛知医科大学 循環器内科
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Ichimiya Satoshi
Department Of Cardiology Kami-iida Daiichi General Hospital
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Isobe Satoshi
Department Of Cardiology Kami-iida Daiichi General Hospital:department Of Cardiology Nagoya Universi
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Matsubara Tatsuaki
Third Department of Internal Medicine, School of Medicine, Nagoya University
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Hotta Nigishi
Third Department of Internal Medicine, Nagoya University
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Matsubara Tatsuaki
Third Department Of Internal Medicine Nagoya University School Of Medicine
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Hotta Nigishi
Third Department Of Internal Medicine Nagoya University School Of Medicine Nagoya
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Hotta Nigishi
Third Department Of Internal Medicine Nagoya University
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Kanashiro Masaaki
Department Of Cardiology Chubu Rosai Hospital
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Matsubara Tatsuaki
Internal Medicine School Of Dentistry Aichi-gakuin University
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Matsubara Tatsuaki
Department Of Internal Medicine Aichi-gakuin School Of Dentistry
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Imai Kenji
Third Department of Internal Medicine, Nagoya University School of Medicine
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Miyahara Takashi
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Imai Kenji
Department Of Cardiology Nagoya University Graduate Of School Of Medicine
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Imai Kenji
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Isobe Satoshi
Division Of Cardiology First Department Of Internal Medicine Nagoya University Graduate School Of Me
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